Effect of neutralization of IL-17 or IL-23 to ear inflammation in IMQ-treated A20 knockout mice.

Abstract

<p>Thickness of IMQ- treated ears of male A20^+/- and A20^+/+ littermate mice with 100 μg/body anti-IL-17 antibody, anti-IL-12p40 antibody, or control IgG2A antibody (R&D Systems) after 6 consecutive days. Antibodies were administrated by intravenous injection the day before the IMQ treatment. Error bars represent SEM; N = 3 or 4 for each group, #<i>p</i> < 0.05 compared to IMQ- and control IgG2A-treated A20^+/+ mice and *<i>p</i> < 0.05 compared to IMQ- and anti-IL-17 antibody-treated A20^+/- mice by Student’s <i>t</i>-test.</p