Treatment with ActRIIB-Fc improves mechanical strength of calluses.

Abstract

<p>ActRIIB-Fc increases callus strength in the four week groups compared to PBS controls in terms of (A) maximum load, (B) stiffness and (C) bending strength. No significant changes were noted between the two week groups. * = p<0.05 n = 6 for PBS 2 weeks, 8 for ActRIIB-Fc 2 weeks, 5 for PBS 4 weeks and 7 for ActRIIB-Fc 4 weeks.</p