LD structures of chromosome 8 locus containing gene UNC5D. (DOCX 3 mb

Birgit Claus Henn (4351825)

Chaolong Wang (140097)

David Bellinger (24603)

David Christiani (72443)

Han Chen (228557)

Li Su (71956)

Lourdes Schnaas (62668)

Maitreyi Mazumdar (3423881)

Martha Tellez-Rojo (4285639)

Molly Kile (71939)

Peter Wagner (577734)

Quan Lu (153192)

Robert Wright (587471)

Ryan Sun (4285636)

Xihong Lin (135298)

Yongyue Wei (391561)

Zhaoxi Wang (71954)

Integrative analysis of direct gene-gene interactions between GWIS genes and in vitro transcriptomic assay genes. (XLSX 18 kb

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Additional file 9: Table S2. of Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

Manhattan plots displaying genetic effects from genome-wide association of meta-analysis on mental or motor composite scores. (DOCX 5 mb

Additional file 5: Figure S4. of Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

The stratified scatterplots show how the effect of Pb on Mental and Motor Composite Score is modified by the number of minor alleles at the two top SNPs. In particular, we can see how both scores appear to fall as Pb increases for subjects with no minor alleles (black symbols), but scores appear to rise as Pb increases for subjects with one minor alleles (blue symbols). This trend occurs for both SNPs and both outcomes, showing the significant interaction effect between the two SNPs and Pb concentration. (DOCX 169 kb

Additional file 4: Figure S3. of Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment