<div>Adhatoda vasica (AV), a popular Indian medicinal plant, is a rich source of polyphenolic</div><div>compounds especially flavonoids which are responsible for strong anti-oxidant</div><div>properties that helps in the therapy of various respiratory diseases. In the present</div><div>investigation, phytochemical screening and gas chromatography mass spectrometry</div><div>analysis of AV leaves was carried out to evaluate the chemical composition in different</div><div>solvent extraction which could be useful in future experimental studies. Phytochemical</div><div>analysis confirmed the presence of alkaloids, flavaones, flavanoids, phytosterols, fixed</div><div>oils, saponins, phenolic compounds, tannins, carbohydrates and glycosides in the</div><div>ethanolic extract comparing to the other extracts. Interestingly, ten anti-inflammatory</div><div>compounds like terpene alcohol, diterpene, linolenic acid, alkaloid, vitamin, steroid and</div><div>sesquiterpene oxide were identified through GC- MS analysis in both the ethanol and</div><div>methanol extract. In conclusion, the ethanol extract is more effective for extracting major</div><div>active compounds and for therapeutic applications.</div