Friction Stir Welding (FSW) is a solid state welding process patented in 1991 by TWI; initially adopted to weld aluminum alloys, is now being successfully used also for magnesium alloys, copper and steels. The wide diffusion the process is having is due to the possibility to weld both materials traditionally considered difficult to be welded or "unweldable" by traditional fusion welding processes due to peculiar thermal and chemical material properties, and complex geometries as sandwich structures and straightening panels. Recently, research is focusing on titanium alloys thanks to the high interest that such materials are getting from the industry due to the extremely high strength-weight ratio together with good corrosion resistance properties. At the moment, the main limit to the industrial applicability of FSW to titanium alloys is the tool life, as ultra wear and deformation resistant materials must be used. In this paper a, experimental study of the tool life in FSW of titanium alloys sheets at the varying of the main process parameters is performed. Numerical simulation provided important information for the fixture design and analysis of results. Tungsten and Rhenium alloy W25Re tools are found to be the most reliable among the ones considered
