<p>Two new flavonoid glycosides, kaempferol 3-<i>O</i>-<i>α</i>-L-rhamnopyranosyl (1→6) (3′′-acetyl)-<i>β</i>-D-galactopyranoside <b>1</b> and kaempferol 3-<i>O</i>-<i>α</i>-L-arabinopyranosyl-5-<i>O</i>-<i>α</i>-L-rhamnopyranoside <b>2</b>, along with six known ones <b>3–8</b> were isolated from the flowers of <i>Vicia faba</i> L. (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound <b>2</b> showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 μg/mL, respectively. For melanogenesis, compounds <b>2</b>, <b>3</b> and <b>4</b> exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity. The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of <i>Vicia faba</i> flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.</p
