<p><b>A</b>. Main effect of reward anticipation, cluster-level corrected at the whole-brain level (pFWE < 0.05). Color bars reflect T-values. <b>B</b>. Diagnosis effects in the anatomical region of interest (ROI) of the ventral striatum. <b>C</b>. Negative correlation of the microbiome function CDT (see <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183509#pone.0183509.g004" target="_blank">Fig 4</a></b>) with reward anticipation responses across the whole-brain (n = 28), intensity threshold at p < 0.001 uncorrected (T = 3.45). The clusters in bilateral ventral striatum (x = -11, y = 11, z = -9, cluster size = 8, p(FWE, cluster) = 0.024; x = 11, y = 6, z = -11, cluster size = 2, p(FWE, cluster) = 0.036) are significant after correcting for multiple comparisons across the search volume (cluster-level pFWE < 0.05, SVC), i.e. the anatomically defined ventral striatum shown in panel B. SVC = small volume correction. * indicates p < 0.05.</p
