<p>Proteins that were not reported in previous studies are shaded in purple. (A) Mitochondrial protein import and folding apparatus. Colored lines represent proteins destined for the outer mitochondrial membrane (blue), inner mitochondrial membrane (green and orange), and mitochondrial matrix (purple). Numbers correspond to the protein number in the complex (e.g., TOM40). Proteases are depicted with partial circles. (B) Mitochondrial carriers from solute carrier protein (SLC) family 25A and their predicted cargo. (C) Metabolic features highlighting the MRO’s role in energy generation and amino acid and lipid metabolism. Protein descriptions are outlined in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2003769#pbio.2003769.s024" target="_blank">S3 Data</a>. Standard amino acid abbreviations are used: Ace, acetate; ACP, acyl carrier protein; aKG, alpha-ketoglutarate; BCD, branched chain amino acid degradation; Carn, Carnitine; CDP-DAG, cytidine diphosphate diacylglycerol; CL, cardiolipin; DHAP, dihydroxyacetone phosphate; DHOro, dihydroorotate; Fd, Ferredoxin; Fum, fumarate; Gly3P, glycerol-3-phosphate; Mal, malate; MMC, methyl-malonyl-CoA; Nd(p), NAD(P); Oaa, oxaloacetate; Oro, orotate; PA, phosphatidic acid; PE phosphatidylethanolamine; Pep, phosphoenol pyruvate; PI, phosphatidylinositol; Prop, propionate; PS, phosphatidylserine; Q<sup>O/R</sup>, quinone/quinol, oxidized or reduced; RQ, rhodoquinone; SAHC, S-adenosylhomocysteine; SAM, S-adenosylmethionine; Suc, succinate; THF, tetrahydrafolate; ThiMP, thiamine monophosphate; ThiPP, thiamine pyrophosphate; UQ, ubiquinone. Data for this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2003769#pbio.2003769.s024" target="_blank">S3 Data</a>.</p
