Additional file 4: Figure S4. of System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia
Outcomes produced by other regulatory sturctures. Apparently false dynamics resulted by other hypotheses of regulations. Basically, all the other network structures than the one in Fig. 5/Additional file 1: Figure S1 produce qualitatively false results on (at least) one of Cdk4/6:CyclinD, Cdk2:CyclinE, and E2F. Here we show the most typically false results, combinations of regulatory relations are randomly assigned. Upper panel: unrealistic dynamic levels of Cdk2:CyclinE and E2F with respect to Maff transcription under low Egr3 expression, which is dictated by a randomly assigned network structure (regulatory code 1212); middle panel: results of Cdk2:CyclinE and E2F dictated by another network structure (regulatory code 2133); results of Cdk4/6:CyclinD and E2F dictated by a third different network structure (regulatory code 3321). Refer to Additional file 7: Table S1 for depiction of the regulatory codes. (PNG 52Â kb
