Additional file 2: Figure S2. of System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia
Simulation results with additional regulation “Maff → Cdk2 (:Cyclin E)” with respect to Maff. Dynamics with respect to the transcription rate of Maff at high (upper), medium (middle), and low (lower) Egr3 expression-levels. In each panel, steady-state molecular quantities of Cyclin D-Cdk4/6 (left), Cyclin E-Cdk2 (middle) and E2F (right) are shown. The correct bistability with respect to Maff is qualitatively reproduced with the additional molecular action. (PNG 73 kb
