octobre 19361936/10 (A3)-1936/10.Appartient à l’ensemble documentaire : RhoneAlp

Joshua Hagen (1978861)

Melanie Tomczak (1978855)

Morley Stone (1650613)

Nancy Kelley-Loughnane (1462666)

Rajesh Naik (1541359)

Wanda Lyon (366107)

Yaroslav Chushak (1978858)

Gallica, Bibliotheque Numerique

Foyer-magazine : revue mensuelle

Biomarkers which are indicative of acute physiological
and emotional
states are studied in a number of different areas in cognitive neuroscience.
Currently, many cognitive studies are conducted based on programmed
tasks followed by timed biofluid sampling, central laboratory processing,
and followed by data analysis. In this work, we present a sensor platform
capable of rapid biomarker detection specific for detecting neuropeptide
orexin A, found in blood and saliva and known as an indicator of fatigue
and cognitive performance. A peptide recognition element that selectively
binds to orexin A was designed, characterized, and functionalized
onto a zinc oxide field effect transistor to enable rapid detection.
The detection limit using the sensor platform was sub-picomolar in
water, and picomolar to nanomolar levels in saliva and serum. The
transistor and recognition element sensor platform can be easily expanded,
allowing for multiple biomarkers to be detected simultaneously, lending
itself to complex biomarker analysis applicable to rapid feedback
for neuroscience research and physiological monitoring

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Detection of Orexin A
Neuropeptide in Biological Fluids
Using a Zinc Oxide Field Effect Transistor

http://gallica.bnf.fr/ark:/12148/cb327769754/date

Foyer-magazine : revue mensuelle

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Gallica, Bibliotheque Numerique

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