SGN projections in the basal turns of cochleae of WT and <i>Nrp1</i><sup><i>fl/fl</i></sup>;<i>Pax2</i><sup><i>Cre</i></sup> mice at P5 and 4-month-old age.
<p>Disorganized outer spiral bundles were evident in cochleae of the <i>Nrp1</i><sup><i>fl/fl</i></sup>;<i>Pax2</i><sup><i>Cre</i></sup> mice (P5) in the basal turn (n = 3 per group). The arrow shows disorganized outer spiral bundles (B). TUJ1 immunostaining of the SGN fibers extending into the inner and outer hair cell regions in 4-month-old <i>Nrp1</i><sup><i>fl/fl</i></sup>;<i>Pax2</i><sup><i>Cre</i></sup> mutants revealed aberrant axons with abnormal innervation of the OHCs. Arrow shows abnormal innervation of the OHCs (D). WT mice did not show aberrant axon migration or innervation. Scale bar = 20 μm.</p
