A new
anthraquinone-fused enediyne, yangpumicin A (YPM A, <b>1</b>), along with four Bergman cyclization congeners (YPM B–E, <b>2</b>–<b>5</b>), was isolated from <i>Micromonospora
yangpuensis</i> DSM 45577 after mining enediyne biosynthetic
gene clusters from public actinobacterial genome databases and prioritizing
the hits by an enediyne genome neighborhood network analysis for discovery.
YPM A is potent against a broad spectrum of human cancer cell lines.
The discovery of <b>1</b> provides new opportunities for the
functionalization of enediynes to develop new conjugation chemistries
for antibody–drug conjugates
