<p></p><p></p><p></p><p>(A) Changes of the improved, slightly improved, stable, slightly progressed, progressed and fluctuated categories.</p><p>···▲···: Improved, ··△···: Slightly improved, ─●─: Stable.</p><p>---□---: Slightly progressed, ---■---: progressed, ─■─: Fluctuated</p><p>Differences in the CAL changes over 24 months were classified into six categories: ≤ -3 mm, improved; between -3 mm and -2 mm, slightly improved; between -1 mm to 1 mm, stable; between 1 mm and 2 mm, slightly progressed; 3mm, progressed. In addition, cases with both ≤ -3 mm and ≥ 3mm were classified as fluctuated.</p><p></p><p></p><p>(B) CAL progression patterns of the progressed category</p><p>···▲···: Cluster 1, ···△···: Cluster 2, ─●─: Cluster 3.</p><p>─□─: Cluster 4, —■—: Cluster 5</p><p>A hierarchical cluster analysis was performed for the progressed type portrayed in Fig. 2(A), and 5 clusters were generated. The slope of cluster 1 was moderate, and the slopes of the other clusters were steep. Cluster 1 may correspond to the linear-type progressed sites, and the other clusters may correspond to the burst-type progressed sites.</p><p></p><p></p><p></p> <p>(A) Changes of the improved, slightly improved, stable, slightly progressed, progressed and fluctuated categories.</p> <p>···▲···: Improved, ··△···: Slightly improved, ─●─: Stable.</p> <p>---□---: Slightly progressed, ---■---: progressed, ─■─: Fluctuated</p> <p>Differences in the CAL changes over 24 months were classified into six categories: ≤ -3 mm, improved; between -3 mm and -2 mm, slightly improved; between -1 mm to 1 mm, stable; between 1 mm and 2 mm, slightly progressed; 3mm, progressed. In addition, cases with both ≤ -3 mm and ≥ 3mm were classified as fluctuated.</p> <p>(B) CAL progression patterns of the progressed category</p> <p>···▲···: Cluster 1, ···△···: Cluster 2, ─●─: Cluster 3.</p> <p>─□─: Cluster 4, —■—: Cluster 5</p> <p>A hierarchical cluster analysis was performed for the progressed type portrayed in Fig. 2(A), and 5 clusters were generated. The slope of cluster 1 was moderate, and the slopes of the other clusters were steep. Cluster 1 may correspond to the linear-type progressed sites, and the other clusters may correspond to the burst-type progressed sites.</p
