Aurore Louf-Durier (4664242)

Claude Guérin (3409154)

Florent Gobert (4664251)

Floriane Lissonde (4664257)

Hodane Yonis (4664239)

Jean-Christophe Richard (26640)

Laurent Bitker (4664245)

Mylène Aublanc (4664248)

Romain Tapponnier (763186)

Sophie Debord (4664263)

Sophie Perinel Ragey (4664254)

Zakaria Riad (4664260)

Critical Care

Diagnostic performance of end-expiratory occlusion to predict fluid responsiveness as a function of change in CVP (ΔCVP) during the test as compared to baseline. (DOCX 14 kb

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Additional file 5: Table S1. of Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation

Gallica, Bibliotheque Numerique

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

MylĂ¨ne Aublanc (4664266)

Claude GuĂŠrin (3409157)

Additional file 3: Figure S2. of Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndromeÂ in the prone position under protective ventilation

Abstract Background Predicting fluid responsiveness may help to avoid unnecessary fluid administration during acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate the diagnostic performance of the following methods to predict fluid responsiveness in ARDS patients under protective ventilation in the prone position: cardiac index variation during a Trendelenburg maneuver, cardiac index variation during an end-expiratory occlusion test, and both pulse pressure variation and change in pulse pressure variation from baseline during a tidal volume challenge by increasing tidal volume (VT) to 8 ml.kg-1. Methods This study is a prospective single-center study, performed in a medical intensive care unit, on ARDS patients with acute circulatory failure in the prone position. Patients were studied at baseline, during a 1-min shift to the Trendelenburg position, during a 15-s end-expiratory occlusion, during a 1-min increase in VT to 8 ml.kg-1, and after fluid administration. Fluid responsiveness was deemed present if cardiac index assessed by transpulmonary thermodilution increased by at least 15% after fluid administration. Results There were 33 patients included, among whom 14 (42%) exhibited cardiac arrhythmia at baseline and 15 (45%) were deemed fluid-responsive. The area under the receiver operating characteristic (ROC) curve of the pulse contour-derived cardiac index change during the Trendelenburg maneuver and the end-expiratory occlusion test were 0.90 (95% CI, 0.80–1.00) and 0.65 (95% CI, 0.46–0.84), respectively. An increase in cardiac index ≥ 8% during the Trendelenburg maneuver enabled diagnosis of fluid responsiveness with sensitivity of 87% (95% CI, 67–100), and specificity of 89% (95% CI, 72–100). The area under the ROC curve of pulse pressure variation and change in pulse pressure variation during the tidal volume challenge were 0.52 (95% CI, 0.24–0.80) and 0.59 (95% CI, 0.31–0.88), respectively. Conclusions Change in cardiac index during a Trendelenburg maneuver is a reliable test to predict fluid responsiveness in ARDS patients in the prone position, while neither change in cardiac index during end-expiratory occlusion, nor pulse pressure variation during a VT challenge reached acceptable predictive performance to predict fluid responsiveness in this setting. Trial registration ClinicalTrials.gov, NCT01965574 . Registered on 16 October 2013. The trial was registered 6 days after inclusion of the first patient

Hodane Yonis

Laurent Bitker

Mylène Aublanc

Sophie Perinel Ragey

Zakaria Riad

Floriane Lissonde

Aurore Louf-Durier

Sophie Debord

Florent Gobert

Romain Tapponnier

Claude Guérin

Jean-Christophe Richard

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Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation

Yonis, Hodane

Bitker, Laurent

Aublanc, Mylène

Perinel Ragey, Sophie

Riad, Zakaria

Lissonde, Floriane

Louf-Durier, Aurore

Debord, Sophie

Gobert, Florent

Tapponnier, Romain

Guérin, Claude

Richard, Jean-Christophe

HAL-UJM

Crossref

Additional file 7: of Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndromeÂ in the prone position under protective ventilation

https://figshare.com/articles/Additional_file_5_Table_S1_of_Change_in_cardiac_output_during_Trendelenburg_maneuver_is_a_reliable_predictor_of_fluid_responsiveness_in_patients_with_acute_respiratory_distress_syndrome_in_the_prone_position_under_protective_ventilation/5674111

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