<p>(A) Tumor weight on day 53. (B) Kinetics of tumor growth. (C) Score for microvessel density (MVD) measured in tumor tissue sections stained with anti-CD31 antibody. (D) Microphotographs of tumor tissue stained with anti-CD31 antibody from control and clopidogrel treated mice. (E) Expression of E- and N-cadherin in tumor tissue (left graph), E:N-cadgherin ratio (middle) and representative blots (right). (F) Morphological parameters of platelets, including platelet count, platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT). (G) ELISA measurements of plasma proteins connected with platelets activity: von Willebrant factor (vWF) and thromboxane B2 (TXB2). All graphs show values for individual animals with median line; the exception is panel E: mean with standard error of mean (SEM) and B: mean with standard deviation (SD) is presented. All mice were euthanized on day 53. N = 6–9 mice per group; some tests were performed on tissue or plasma from selected animals from each group (at least 3 for western blot; data for individual blots presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188740#pone.0188740.s015" target="_blank">S1 Table</a>). Statistical analysis: Kruskal–Wallis test for multiple comparisons; *<i>p</i><0.05. The values of selected platelet parameters for healthy C57Bl/6 mice: platelet count: 571 ± 94 [×10<sup>3</sup>/μL]; MPV: 5.4 ± 0.2 [fL]; PDW: 41 ± 4 [fL]; PCT: 0.3 ± 0.04 [%].</p
