Age-standardized Prevalence (95% Confidence Intervals) of Chronic Obstructive Pulmonary Disease in Current Smokers according to intensity and duration exposure. (DOCX 14 kb

Adolfo Rubinstein (308007)

Allison Lee (4677154)

Chung-Shiuan Chen (318759)

Edgardo Sobrino (4677148)

Fernando Lanas (3221271)

Jacqueline Ponzo (3221253)

Jiang He (216340)

Laura Gutierrez (3221265)

MatĂ­as Calandrelli (4677157)

Nora Mores (3221277)

Pamela SerĂłn (4677151)

Vilma Irazola (308006)

BMC Pulmonary Medicine

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Additional file 6: Table S4. of Estimating prevalence of chronic obstructive pulmonary disease in the Southern Cone of Latin America: how different spirometric criteria may affect disease burden and health policies

Atelier Nadar. Photographe

Gallica, Bibliotheque Numerique

Bellot. Renaissance. Cocard et Bicoquet : [photographie, tirage de démonstration] / [Atelier Nadar]

Percentage of non-respondents or excluded participants by location, sex, age, education and smoking status. (DOCX 15 kb

Additional file 1: Table S1. of Estimating prevalence of chronic obstructive pulmonary disease in the Southern Cone of Latin America: how different spirometric criteria may affect disease burden and health policies

Abstract Background Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The study aimed to determine and compare the prevalence of COPD in the general population aged 45-74 years old according to fixed ratio and lower limit of normal (LLN) thresholds in four cities in the Southern Cone of Latin America. Methods The Pulmonary Risk in South America (PRISA) study used a 4-stage stratified sampling method to select 5814 participants from 4 cities in the Southern Cone of Latin America (Bariloche and Marcos Paz, Argentina; Temuco, Chile; and Pando-Barros Blancos, Uruguay). Data on demographic information, medical history, risk factors, pre-bronchodilator and post-bronchodilator spirometry were obtained using a standard protocol. According to GOLD, COPD was defined as a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) over forced vital capacity (FVC) less than 70%. The LLN threshold was defined as the lower fifth percentile for predicted FEV1/FVC, and was evaluated as an alternative COPD definition. Results Overall COPD prevalence was 9.3% (95% CI 8.4, 10.2%), and men had a higher prevalence [11.8% (95% CI 10.3, 13.3%)] than women [7.3% (95% CI 6.2, 8.3%)] with the fixed ratio. Overall COPD prevalence using LLN was 4.7% (95% CI 4.1, 5.3%), higher in men: 5.8% (95% CI 4.7, 6.8%) than women: 3.9% (95% CI 3.1, 4.7%). COPD prevalence was significantly higher among those who were older, had <high-school education and lower body-mass index, were cigarette smokers, and had self-reported history of asthma and tuberculosis. Conclusions First, COPD and its risk factors are highly prevalent in the general population of Argentina, Chile, and Uruguay. Second, the prevalence of COPD by LLN criterion was significantly lower with lesser degrees of severity compared to fixed ratio of FEV1/FVC. Implementing LLN criterion instead of fixed ratio of FEV1/FVC may reduce the risk of over-diagnosis of COPD, although further prognostic studies of COPD adverse outcomes should be conducted using both definitions. Third, these data suggest that national efforts on the prevention, treatment, and control of COPD should be a public health priority in the Southern Cone of Latin America

Edgardo Sobrino

Vilma E. Irazola

Laura Gutierrez

Chung-Shiuan Chen

Fernando Lanas

Matías Calandrelli

Jacqueline Ponzo

Nora Mores

Pamela Serón

Allison Lee

Jiang He

Adolfo L. Rubinstein

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Estimating prevalence of chronic obstructive pulmonary disease in the Southern Cone of Latin America: how different spirometric criteria may affect disease burden and health policies

http://catalogue.bnf.fr/ark:/12148/cb45305257d

Bellot. Renaissance. Cocard et Bicoquet : [photographie, tirage de démonstration] / [Atelier Nadar]

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