<p>The aim of the study was to isolate digestive enzymes inhibitors from <i>Mimosa pudica</i> through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC<sub>50</sub> values as compared to acarbose (351.02 ± 1.46 μg mL<sup>−1</sup>) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL<sup>−1</sup>, respectively. In conclusion, <i>M. pudica</i> could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.</p> <p>Antidiabetic active principles (stigmasterol, quercetin, avicularin) isolated from neglected weed <i>Mimosa pudica</i></p
