This paper discusses the extraction of behavioral models of differential drivers with pre-emphasis for the assessment of signal integrity and electromagnetic compatibility effects in multigigabit data transmission systems. A suitable model structure is derived and the procedure for its estimation from port transient waveforms is illustrated. The proposed methodology is an extension of the macromodeling based on parametric relations applied to plain differential drivers. The obtained models preserve the accuracy and efficiency strengths of behavioral parametric macromodels for conventional devices. A realistic application example involving a high-speed communication path and a 3.125 Gb/s commercial driver model with pre-emphasis is presente