Brain lateralization is the phenomenon that both hemispheres of the brain are specialised in different functions. Lateralization differs in strength and direction between individuals and among tasks within individuals, potentially affecting cognitive performance. There is debate to what extent individual differences in lateralization are due to early or later exposure to sex hormones. We use unique data sets to test this: (1) Existing data on prenatal hormone exposure, obtained from amniotic fluid during pregnancy of the mothers, will be correlated with brain lateralization and cognitive performance in a group of healthy adolescents of 13-15 years old (30 boys, 30 girls). (2) Current testosterone and progesterone levels are measured in saliva and will be correlated with brain lateralization and cognitive performance of the same individuals. Brain lateralization of verbal fluency, mental rotation and facial emotion processing is measured with functional transcranial Doppler s! onograph

Beking, Tess

Geuze, Reint

Groothuis, Antonius

ARTS repository - University of Groningen

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 09-09-2023There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

English

The influence of sex hormones on brain lateralisation

University of Groningen Research Database

  
 University of Groningen
The influence of sex hormones on brain lateralisation
Beking, Tess; Geuze, Reint; Groothuis, Ton
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2015
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Poster
session presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the
author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately
and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the
number of authors shown on this cover page is limited to 10 maximum.
Download date: 11-02-2018
There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to 
sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows: 
  
1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  
2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment 
 
 
 
Prenatal hormones 
Amniocentesis was performed within the 14th-19th week of 
pregnancy, the same period as brain lateralisation is assumed to be 
modulated by the influence of steroid hormones. The children born 
from these pregnancies are 15 years old now. 
 
Subjects 
 
 
 
 
fTCD 
Brain lateralisation will be measured with  
functional Transcranial Doppler sonography.  
fTCD measures the difference between the  
left and right hemisphere in blood flow  
velocity in the Middle Cerebral Arteries  
during a cognitive task.  
 
Tasks 
Individual strength and direction of lateralisation will be assessed 
during 3 tasks: 
                                    Mental rotation            Chimeric faces 
 
 
 
 
 
                                 Word generation 
 
 
 
Additional data 
-  Current hormone levels 
-  Handedness 
-  Aggression, Empathy  
-  Pubertal stage, Gender identity & Sexual orientation 
 
 
 
 
 
1. Suggestions for essential measurements in the “Prenatal hormones study”? 
2. How to analyze lateralisation in existing fMRI-data? 
 
1. Prenatal testosterone masculinizes strength and direction of lateralisation1 
2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD 
 
T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 
1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  
Hormones later in life 
Individuals with Gender Dysphoria experience a strong 
incongruence between their gender identity and natal sex. Many 
individuals with Gender Dysphoria undergo cross-sex hormone 
treatment to align their body with their gender identity.  
 
Subject groups 
Treatment in adolescence: 
 
 
 
Treatment in adulthood:  
 
 
 
Group comparisons 
The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls 
 
The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls 
 
The effect of cross-sex hormones on lateralisation in adolescents: 
(GD cross-sex – GD puberty suppression) vs. controls 
 
The effect of cross-sex hormones on lateralisation in adults:  
(GD  cross-sex – GD gonadal suppression) vs. controls 
 
fMRI 
Brain lateralisation will be measured with fMRI. 
 
Tasks 
Word generation, Mental rotation and Facial emotion recognition. 
 
Additional data: 
-  Current hormone levels 
-  In some cases: Diffusion Tensor Imaging, Voxel-based                                        
morphometry or Resting state connectivity 
 
 
Amniocentesis fTCD-study (25♂, 25♀) 
No treatment Puberty suppression 
Cross-hormone treatment Gonadal suppression 
Cross-hormone treatment 
Prenatal 15 y 
8-11 y 
18-40 y 
16-18 y 
  
 
15-17 y 
18-40 y 
K 
“Kind, kit, 
etc...” 
1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  
fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46. 
  
  


Dissertations of the University of Groningen

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 31-10-2023There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

Proceedings - University of Groningen

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 21-06-2022There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 29-10-2022There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

University of Groningen

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 12-11-2019There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

   University of GroningenThe influence of sex hormones on brain lateralisationBeking, Tess; Geuze, Reint; Groothuis, AntoniusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Beking, T., Geuze, R., & Groothuis, A. (2015). The influence of sex hormones on brain lateralisation. Postersession presented at NVG Annual General Meeting 2015, Soesterberg, Netherlands.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 28-12-2022There is long standing debate to what extent variation in lateralisation between and within individuals is due to early or late exposure to sex hormones. The relation between sex hormone exposure and functional lateralisation will be investigated as follows:   1.  Correlate existing data on prenatal hormone exposure with brain lateralisation in healthy children of 15 years  2.  Analyze brain lateralisation in individuals with Gender Dysphoria (GD) before and after hormone treatment    Prenatal hormones Amniocentesis was performed within the 14th-19th week of pregnancy, the same period as brain lateralisation is assumed to be modulated by the influence of steroid hormones. The children born from these pregnancies are 15 years old now.  Subjects     fTCD Brain lateralisation will be measured with  functional Transcranial Doppler sonography.  fTCD measures the difference between the  left and right hemisphere in blood flow  velocity in the Middle Cerebral Arteries  during a cognitive task.   Tasks Individual strength and direction of lateralisation will be assessed during 3 tasks:                                     Mental rotation            Chimeric faces                                       Word generation    Additional data -  Current hormone levels -  Handedness -  Aggression, Empathy  -  Pubertal stage, Gender identity & Sexual orientation      1. Suggestions for essential measurements in the “Prenatal hormones study”? 2. How to analyze lateralisation in existing fMRI-data?  1. Prenatal testosterone masculinizes strength and direction of lateralisation1 2. Hormone treatment influences strength and direction of lateralisation towards the  experienced gender in individuals with GD  T. Beking1, R.H. Geuze1, B.P.C. Kreukels2 & A.G.G. Groothuis3 1 University of Groningen (Clin. & Dev. Neuropsychology), 2Center of Expertise on Gender Dysphoria Amsterdam and 3University of Groningen (Behavioural Biology)  Hormones later in life Individuals with Gender Dysphoria experience a strong incongruence between their gender identity and natal sex. Many individuals with Gender Dysphoria undergo cross-sex hormone treatment to align their body with their gender identity.   Subject groups Treatment in adolescence:    Treatment in adulthood:     Group comparisons The organisational effect on lateralisation: 8-11y GD vs. 8-11y controls  The effect of puberty on lateralisation: 8-11y controls vs. 15-17y controls  The effect of cross-sex hormones on lateralisation in adolescents: (GD cross-sex – GD puberty suppression) vs. controls  The effect of cross-sex hormones on lateralisation in adults:  (GD  cross-sex – GD gonadal suppression) vs. controls  fMRI Brain lateralisation will be measured with fMRI.  Tasks Word generation, Mental rotation and Facial emotion recognition.  Additional data: -  Current hormone levels -  In some cases: Diffusion Tensor Imaging, Voxel-based                                        morphometry or Resting state connectivity   Amniocentesis fTCD-study (25♂, 25♀) No treatment Puberty suppression Cross-hormone treatment Gonadal suppression Cross-hormone treatment Prenatal 15 y 8-11 y 18-40 y 16-18 y    15-17 y 18-40 y K “Kind, kit, etc...” 1Previous study: Lust, J. M., Geuze, R. H., Van de Beek, C., Cohen-Kettenis, P. T., Groothuis, A. G. G., & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48(2), 536–40.  fTCD: Deppe, M., Ringelstein, E. B., & Knecht, S. (2004). The investigation of functional brain lateralization by transcranial Doppler sonography. NeuroImage, 21(3), 1124–46.     

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The influence of sex hormones on brain lateralisation

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