PRODUCTION OF HIGHLY PURE NO-CARRIER ADDED ZR-89 FOR THE LABELING OF ANTIBODIES WITH A POSITRON EMITTER

Abstract

Zr-89 was produced in high amounts (130 mCi/h) via a (p,n) reaction on Y-89. The Zr-89-isotope was purified using a hydroxamate column. More than 95% of the Zr was eluted with 1 mt of 1 M oxalic acid. The radionuclidic purity was over 99.99%. The isolated Zr-89 quantitatively formed complexes with the chelating agent desferal at low concentrations (10-100 mu M)