Bron, S

Holsappel, S

Kiewiet, R

Noback, M.A

Terpstra, P

Venema, G

Wambutt, R.

Wedler, H.

University of Groningen

The 172 kb prk-addAB region from 83E to 97E of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitos hit gene

A 171 812 bp nucleotide sequence betweenprkA andaddAB(83° to 97°) on the genetic map of theBacillus subtilis168 chromosome was determined and analysed. An accurate physical/genetic map of this previously poorly described chromosomal region was constructed. One hundred and seventy open reading frames (ORFs) were identified on this DNA fragment. These include the previously described genes cspB, glpPFKD, spoVR, phoAIV, papQ, citRA, sspB, prsA, hpr, pbpF, hemEHY, aprE, comKandaddAB. ORF yhaFin this region corresponds to the glyB marker. Among the striking features of this region are: an abundance of genes encoding (putative) transporter proteins, several dysfunctional genes, the ubiquitous hit gene, and five multidrug-resistance-like genes. These analyses have also revealed the existence of numerous paralogues of ORFs in this region: about two-thirds of the putative genes seem to have at least one paralogue in theB. subtilis genom

The 172 kb prk-addAB region from 83E to 97E of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitos hit gene

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University of Groningen

Proceedings - University of Groningen

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Dissertations of the University of Groningen

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