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Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP
Authors
A. Comment
P. Hautle
+8 more
S. Jannin
J. A. Konter
F. Kurdzesau
J. Rentsch
K. Uffmann
B. van den Brandt
J. J. van der Klink
R. B. van Heeswijk
Publication date
26 May 2012
Publisher
'Elsevier BV'
Doi
Cite
Abstract
New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with nitroxyl free radicals. The obtained 13C low-temperature polarization was comparable to the one measured on 20 times smaller sample volume with only 3-4 times higher microwave power. By using a dissolution insert that fits to the new design, it was possible to obtain about 120 ml of room-temperature hyperpolarized solution. The polarization as well as the molecule concentration was comparable to the values obtained in standard size hyperpolarized samples. Such large samples are interesting for future studies on larger animals and possibly for potential clinical applications. © 2008 Elsevier Inc. All rights reserved
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Infoscience - École polytechnique fédérale de Lausanne
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Last time updated on 09/02/2018