Multiple transposable elements have been identified by colocalization analysis that display a strong predicted regulatory relationship with p53 associated peaks. RNA-Seq was used to identify differentially expressed transposable elements. ChIP-Seq was used to identify peaks representing transcription factor binding sites in p53 activated cells. The results of both experiments were then combined in a colocalization analysis identifying transposable element locations that were both differentially regulated and located near p53 associated peaks. The colocalization of ChIP-Seq and RNA-Seq analyses allows for the verification of p53’s regulatory role in the expression of transposable elements across the genome. A Monte Carlo simulation was performed verifying that the frequency of the colocalizations observed occurred more frequently than due to random chance
