Howard, E.

Wang, Xiang Hong

Wong, Y. C.

English

Wong Y. C.

Howard E.

Wang Xiang Hong

University of Szeged

V o l u m e 5 1 ( S u p p l . 1 ) 2007 A c t a Bio logica Szegediensis http://www.sci.u-szeged.hu/ABS Garlic extracts working in concert with docetaxel to suppress the growth of androgen independent (Al) prostate cancer YC Wong*, E Howard, XH Wang Cancer Biology Lab, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, HKSAR, China Androgen independent prostate cancer (AIPC) is an end stage prostate cancer characterized by bone metastasis and with few therapeutic options. Docetaxel has been shown recently to have significant effect on treatment of AIPC but unfortunately the strategy, though significant statistically, was modest with only about 2.5 months in survival advantage due to intolerance and resistance to docetaxel therapy. Recently we have shown that garlic extracts such as SAC (S-allylcysteine) and SAMC (S-allylmercaptocysteine) could effectively suppress the proliferation, migration and invasion of AIPC cells under in vitro condition (Chu et al. 2(X)6). This inhibitory effect was associated with induction of mesenchymal to epithelial transition. More importantly, the SAC and SAMC treatment led to restoration of E-cadherin expression while the expression of E-cadherin repressor, Snail, was downregulated. We have also studied the effect of these compounds on prostate cancer under in vivo condition using CWR22R. an Al prostate cancer xenograft in nude mice. The results showed that treatment with the garlic derivatives inhibited the growth of CWR22R without any detectable toxic effect on nude mice. The SAC and SAMC induced growth reduction was correlated with a reduction in serum PSA level and proliferation rate of xenografts (Chu et al. 2006). Our latest study revealed that SAMC could sensitize the action of docetaxel on AIPC under both in vitro and in vivo condi-tions. Overall our results suggest that these garlic derivatives may be potential therapeutic agents for the suppression of Al prostate cancer either alone or as a potent adjunct to docetaxel therapy for AIPC patients. Combination of garlic extract with docetaxel may allow lowering of the latter dosage, thus enhancing the effectiveness of docetaxel on one hand while reducing the toxicity on the other hand.|Supported by AICR (05A006-REV2) and RGC grants (HKU7478/03M) to XHW and YCW (HKU7490.03M. 7470/04M. NSFC/RGCN HKU738/03, HKU Foundation Seed Fund, 03)]. Chu QJ. Ling MT. Cheung HW. Wang G. Tsao SW. Wang XH. Wong YC (2006) A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression. Carcinogenesis 27:2180-2189. Chu QJ. Lee DTW. Tsao SW. Wang XH. Wong YC (2006) S-allylcysteine. a water soluble garlic derivative, suppresses the growth of CWR22R. a human androgen-independent prostate cancer under in vivo condition. British J Urology International 99:925-932. •Corresponding author E-mail: yewongfa hkucc.hku.hk Analysis and standardization of the anastomoses between the segmental branches of the portal hepatic vein. Study on corrosion casts DE Zahoi, P Matusz*, AM Pusztai, D Sztika, E Pop Department of Anatomy, Faculty of Medicine, University of Medicine and Pharmacy Victor Babes Timisoara, Romania The right and left branch of the portal hepatic vein are placed into the fissures of the venous segmentation of the hepatic pa-renchyma. areas considered as paucivascular from the point of view of the elements forming the efferent pedicle of the liver (hepatic veins and their affluents). The right branch of the portal hepatic vein gives birth to the anterior and to the posterior branch. From the umbilical portion of the left branch arise the medial branches and the lateral branches. The lateral branches (superior and inferior) go to the left lateral division (S II and S III), the medial branches go to the left medial division (S IV), the anterior branch goes to the right medial division (S V and S VI I I ) and the posterior branch goes to the right lateral divi-sion (S VI and S VII). Numerous authors described liver's parenchyma segmentation based on the terminal character of the branches of the portal hepatic vein. All the same, in the anatomical literature anastomoses between the segmental branches of the portal hepatic vein are described in the normal liver. In order to demonstrate the anastomoses between the segmental 57 

Garlic extracts working in concert with docetaxel to suppress the growth of androgen independent (Al) prostate cancer

http://acta.bibl.u-szeged.hu/22891/1/biologica_051_numb_001_suppl_057.pdf

Garlic extracts working in concert with docetaxel to suppress the growth of androgen independent (Al) prostate cancer

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