baets, roel

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Ghent University Academic Bibliography

  1 9 t h  E U R O P E A N  C O N F E R E N C E  O N  I N T E G R A T E D  O P T I C S  1 Silicon Photonics and its Applications in Life Science Roel Baets1,2* 1Ghent University – imec, Photonics Research Group, Technologiepark-Zwijnaarde 15, 9052 Gent, Belgium 2Ghent University, Center for Nano- and Biophotonics, Belgium * roel.baets@ugent.be With the technology of silicon photonics gaining maturity there is a tendency to consider it as a generic technology that can serve a diverse range of markets, not only in datacom and telecom, but also in sensors, biosensors and biomedical instruments. The driver is always the same: create compact and low-cost integrated circuits with a functionality and performance at par with otherwise bulky and costly implementations. Examples of this trend include PIC’s for sensing bioparticles such as proteins and DNA, PIC’s for spectroscopic detection of various molecules (glucose, ammonia, markers for food spoilage etc), PIC’s for optical coherence tomography or for laser Doppler vibrometry.  In those new applications the “traditional” wavelengths of silicon photonics (1.3 and 1.55 m) are not necessarily optimal from the application’s point of view. This has led to the recent trend to “translate” silicon photonics to other wavelength domains, as much as possible without shying away from its major asset which is to fabricate the chip in a CMOS fab. Many groups are pushing the frontiers of silicon photonics towards longer wavelengths (mid-infrared), mainly driven by the promise of using the technology for vibrational spectroscopy. In parallel other groups are pushing towards shorter wavelengths, so as to be more compatible with biological media, fluorescent markers and Raman spectroscopy. In this case the silicon core needs to be replaced by a material that is transparent in the visible, silicon nitride being a good candidate. In those applications silicon itself changes hat and becomes the near-perfect material for detection. Below a bibliography is given of work the author has been involved in on the use of silicon and silicon nitride PICs in a life science context. References [1] A. Dhakal, P.C. Wuytens, F. Peyskens, K. Jans, N. Le Thomas, R. Baets, Nanophotonic waveguide enhanced Raman spectroscopy of biological submonolayers, ACS Photonics, 3(12), p.2141-2149 (2016). [2] A. Dhakal, F. Peyskens, S. Clemmen, A. Raza, P.C. Wuytens, H. Zhao, N. Le Thomas, R. Baets, Single mode waveguide platform for spontaneous and surface-enhanced on-chip Raman spectroscopy, Interface Focus, 6(4), United Kingdom, p.article 20160015 (2016).  1 9 t h  E U R O P E A N  C O N F E R E N C E  O N  I N T E G R A T E D  O P T I C S    2[3] F. Peyskens, A. Dhakal, P. Van Dorpe, N. Le Thomas, R. Baets, Surface Enhanced Raman Spectroscopy Using a Single Mode Nanophotonic-Plasmonic Platform, ACS Photonics, 3(1), p.102-108 (2016). [4] P.C. Wuytens, A. Subramanian, W. H. De Vos, A. G Skirtach, R. Baets, Gold nanodome-patterned microchips for intracellular surface-enhanced Raman spectroscopy, Analyst, 140(24), p.8080-8087 (2015)  . [5] A. Subramanian, E.M.P. Ryckeboer, A. Dhakal, F. Peyskens, A. Malik, B. Kuyken, H. Zhao, S. Pathak, A. Ruocco, A. De Groote, P.C. Wuytens, D. Martens, F. Leo, W. Xie, U.D. Dave, M. Muneeb, Pol Van Dorpe, Joris Van Campenhout, W. Bogaerts, P. Bienstman, N. Le Thomas, D. Van Thourhout, Zeger Hens, G. Roelkens, R. Baets, Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip , Photonics Research, 5(3), p.B47 (2015)  . [6] G. Yurtsever, Nicolas Weiss, Jeroen Kalkman, Ton G. van Leeuwen, R. Baets, Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography, Optics Letters, 39(17), p.5228-5231 (2014)  . [7] A. Dhakal, A. Subramanian, P.C. Wuytens, F. Peyskens, N. Le Thomas, R. Baets, Evanescent excitation and collection of spontaneous Raman spectra using silicon nitride nanophotonic waveguides, Optics Letters, 39(13), p.4025-4028 (2014). [8] E.M.P. Ryckeboer, R. Bockstaele, M. Vanslembrouck, R. Baets, Glucose sensing by waveguide-based absorption spectroscopy on a silicon chip, Biomedical optics express, 5(5), p.1636-1648 (2014)  . [9] G. Yurtsever, Boris Povazay, Aneesh Alex, Behrooz Zabihian, Wolfgang Drexler, R. Baets, Photonic integrated Mach-Zehnder interferometer with an on-chip reference arm for optical coherence tomography, Biomedical Optics Express, 5(4), p.1050-1061 (2014)  . [10] E.M.P. Ryckeboer, J. Vierendeels, A. Lee, S. Werquin, P. Bienstman, R. Baets, Measurement of small molecule diffusion with an optofluidic silicon chip, Lab on a Chip, 13(22), p.4392 - 4399 (2013)  . [11] Y. Li, P. Segers, J. Dirckx, R. Baets, On-chip laser Doppler vibrometer for arterial pulse wave velocity measurement, Biomedical Optics Express, 4(7), p.1229-1235 (2013)  . [12] N.A Yebo, S. P. Sree, E. Levrau, C. Detavernier, Z. Hens, J. A. martens, R. Baets, Selective and reversible ammonia gas detection with nanoporous film functionalized silicon photonic micro-ring resonator , Optics Express, 20(11), p.11855-11862 (2012)  . [13] N.A Yebo, P. Lommens, Z. Hens, R. Baets, An integrated optic ethanol vapor sensor based on a silicon-on-insulator microring resonator coated with a porous ZnO film, Optics Express, 18(11), p.11859-11866 (2010)  . [14] K. De Vos, Jordi Girones Molera, T. Claes, Y. De Koninck, Stepan Popelka, Etienne Schacht, R. Baets, P. Bienstman, Multiplexed antibody detection with an array of silicon-on-insulator microring resonators, IEEE Photonics Journal, 1(4), p.225-235 (2009)  . [15] T. Claes, J. Girones Molera, K. De Vos, E. Schacht, R. Baets, P. Bienstman, Label-Free Biosensing With a Slot-Waveguide-Based Ring Resonator in Silicon on Insulator, IEEE Photonics Journal, 1(3), p.197-204 (2009)   [16] K. De Vos, J. Girones, S. Popelka, E. Schacht, R. Baets, P. Bienstman, SOI optical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications, Biosensors and Bioelectronics, 24(8), p.2528-2533 (2009)  . [17] K. De Vos, I, Bartolozzi, E, Schacht, P. Bienstman, R. Baets, Silicon-on-Insulator microring resonator for sensitive and label-free biosensing, Optics Express, 15(12), p.7610-7615 (2007) 

Silicon photonics and its applications in life science

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Silicon photonics and its applications in life science

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