We introduce our incremental coreference resolution system for the BioNLP 2011 Shared Task on Protein/Gene Znteraction. The benefits of an incremental architecture over a mentionpair model are: a reduction of the number of candidate pairs, a means to overcome the problem of underspecified items in pair-wise classification and the natural integration of global constraints such as transitivity. A filtering system takes into account specific features of different anaphora types. We do not apply Machine Learning, instead the system classifies with an empirically derived salience measure based on the dependency labels of the true mentions. The OntoGene pipeline is used for preprocessing