The present study has been supported by the Institute of Health ‘Carlos III’ (ISCIII) of the Ministry of Economy and Competitiveness (grants co-funded by European Regional Development Fund (ERDF): PI18/00095, RETICS ARADYAL RD16/0006/0001; Andalusian Regional Ministry Health (PE-0172-    2018). ML is supported by the ‘Río Hortega’ program [CM20/00210] from the ISCIII. CM holds a ‘Nicolas Monardes’ research contract (RC-   0004-    2021) and ID holds an SAS Stabilization contract (ref B-0001-    2017) by Andalusian Regional Ministry Health. Funding for open access charge: Universidad de Málaga / CBU

Agache, Ioana

Céspedes, Jose Antonio

Doña, Inmaculada

Marina, Labella

Mayorga, Cristobalina

Shamji, Mohamed H.

Torres-Jaen, Maria Josefa

Allergy

Spanish

Labella, Marina

Céspedes Lagos, José Antonio

Mayorga Mayorga, Cristobalina

Torres-Jaén, María Josefa

Repositorio Institucional Universidad de Málaga

The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine

mRNA-based COVID-19 vaccines have been reported to induce hypersensitivity reactions (HSR) in a small number of individuals. We aimed to evaluate the real-world incidence of the BNT162b2 mRNA COVID-19 vaccine HSR and to determine the value of the basophil activation test (BAT) in the allergological workup of patients reporting these reactions. We prospectively enrolled patients with a clinical history indicative of HSR to the BNT162b2 mRNA COVID-19 vaccine. The allergological workup included skin testing (STs) and BAT with polyethylene glycol (PEG) and the vaccine. In those with negative allergy assessments, the administration of the second dose of the BNT162b2 mRNA COVID-19 vaccine was offered. Seventeen adults were included. Eleven cases (64.7%) tested negative in the allergological workup and tolerated the re-administration of the second dose of the vaccine and considered non-allergic. Six cases (35.3%) were considered allergic and classified into three groups: 2 subjects displayed positive STs and/or BAT to PEG (Group A), two individuals displayed positive BAT to the vaccine (Group B), and in 2 patients with moderate or severe reactions, the culprit was not identified, tested negative to STs and BAT to both PEG and vaccine (Group C). We further evaluated the value of BAT when the results were positive to the vaccine and negative to PEG by performing BAT in controls groups, finding positive BAT results in 50% of controls, all of them recovered from COVID-19 infection. In contrast, BAT was negative in patients who had not suffered from COVID-19 disease. BAT can be used as a potential diagnostic tool for confirming allergy to PEG excipient but not to the vaccine as a positive result in BAT may indicate a past COVID-19 infection instead of an allergy

Shamji, Mohamed H

Torres, Maria José

REPISALUD

The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine.

Fondo Bibliográfico Digital Institucional

https://riuma.uma.es/xmlui/bitstream/10630/24066/1/Allergy%20-%202021%20-%20Labella%20-%20The%20value%20of%20the%20basophil%20activation%20test%20in%20the%20evaluation%20of%20patients%20reporting%20allergic.pdf

The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine

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Repositorio Institucional Universidad de Málaga

REPISALUD

Fondo Bibliográfico Digital Institucional