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肿瘤早期诊断用隐形造影材料及其制备方法
Authors
吴爱国
沈折玉
Publication date
24 October 2012
Publisher
Abstract
本发明公开了一种肿瘤早期诊断用隐形造影材料及其制备方法,采用可生物降解纳米球包埋医学造影剂、在纳米球的表面偶联与肿瘤细胞有特异性相互作用的靶分子、并接枝pH敏感型高分子。纳米球表面的靶分子在正常生理条件下隐藏在pH敏感型高分子之中,不能与正常细胞的非特异性抗原或受体发生相互作用,故该隐形造影材料不能被正常细胞非特异性摄取;而纳米球表面的靶分子在肿瘤组织环境下由于高分子收缩而暴露出来,与肿瘤细胞表面的抗原或受体发生特异性相互作用,从而实现将隐形造影材料高精准地靶向输送至肿瘤部位,降低医学造影剂的用药剂量、毒副作用和成本
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Last time updated on 22/01/2018