Samadi, Zahra

Simorgh Research Repository

,(y''(\'?UH.u$t.YoYt' ,*i;'N-OL-J ..,rLtc 9,r;Jil*a; cib.ri 9 .rS;ra. pgJc ol5li.Jls)y sl;il.f.r.'qp *S; o.rS-i,.ilcOt"*ljl ;rl:i o,a,a;;.Slr5c c.ib-tJ ca3 a."U 6Ll-'"3glrt1o IVF )l ,'.b 61Lij tf pn--tS f D Cx*Lt- 9 dl4,,t 9 BMI &.ls c#sst)f sLiil.rb-,L*t "d.tjU .i4 a1 o*i;S ar.:tro ,,lf.rL"=tt:ln;al1sE*locll,=L> t-tiS-l F",",1-.r.,*, l,.r.J F",o,t-;drlii g ui.r}qg.r-.- lro;lllt slcri"*; .S-Jlz -q;E JL.S, jl -,+, ;.u ,lr1! ,r ;l;L; Jsy4 g-ljU Srt^.: :arrLe,rty);_l ;Lr:.Sb,-ir; rl..r;iL./ ljtj t*9) rl -r.or.: \A-\. orgr-!.c9;,-/ -.-F,(lUI) Lo .rl-r^;' .rr J;5.S,-r.o olr^o a, f -*l e; .}-l; e=;iL : o.!oe dirr rJ ! ,jtt.lt.r*;l .u;L .sr-,lr- ,.: IIVF; €; esV Cd ,-rs;;l ."-i "rUl (lVF) €; e.sG CW .-4-,.Jlj J-rf ;r Jl:r-;Ult-.J9- d o.:lii;l ;*l *[;U fl_Sy_*l ui-"_,lr s t; dl.+L-" r,-.J,*.:1 t;*if ..s*ytl ";+. !.-,i et' *- LVJ I J:, -lr rcD J"*L,-9A,Jt-t- o.f ;-l s ,s1 .r ;9- Jl;;^ .!,l* t IVF ;;t .:*.ol * 9i L .;rlc c9-=9 .grlorL. D .;"-t'*9 et- dJ^.\) s-D1 ! t'ro,-u;1 ,r;*l oo."ii,"t7dl 9!rr-1 ,-: {-*j dtl ,c,={d['-.ro*jlr-,* IVF ;l &t- eb 1o ,".*5 b :,=,q ory ,n;tlzi.;U; ,[-tc t* ;i;ttU ,-rLj .sl; ; f ".r.,-1 .*lF* J;yo * A,Jt-t- ;.1 .:lo .ir-, : Jl:-.l-( l:;l .l-o-r )x r,.- rr*rL.r.s;i-,tlL -Sr * IVF,Ut ;a-= a5 (a;l.:r-,l.tc JL=c;9.t)At.? t s)t)9 gila;l::r" y,-> t r!rL* *,-< e$l 1A r:n-l lJ 1f r:;l 1l , s.:rf a.-ly( JU::11 l; jr_, -,. D.r"-b-i i e-Jf ih- 6-S o,lll ;,4-7 of on?..r.;u aJlL" c-,,1,b Cr.r+ ;i.5..u ,r1L-;rl ,*.;l*ry,.sto J;-i ,rLl -*.S^;'cJ*5. ".: o:r.5.-,lrL* jl.grt.rap:: 6ly *- ri rfef . kfL-f-, ;-i.5 ..;." .tll,r , oJ.J l*jl,,, ;;- cl-r-; . &.: J"*,i iJ9 \ Y .91o19, ,o .grl:,,! )lt ;q rl . IVF ft7.;! jl -*. ..l-i JiinJ ,* ,-Sb .-fS* .uL 9 Q;lc.s-;t r-,,f *-(;*5,.,<L[.- Gl-f yy Ly.,*r-, + PhCG,rL-9, JU:t ,l ,J-" \f.c-3f )rc.i- j$i* rlr jt-;; ;i; e$l rL-* f . .Sl_, I aS r;V a-JtL 61L:; :Lo citl.L-rlJ Y' ,.: cl: .-,1 '.-r D -,=.1;-l -r*ol d;y y Ly.f C,-Ll .J-jiL* JL Yf/f L+l..l .rt c9.-J ',i ,l ' :. (r-i \ \ ) .r-or.: YY/A ,c .i*l Jt-; ;t ,t.u;- (rji \ Y) ;lrt*.rJ-r-;.:rd (j-.u f ) ,lrl"* r-r)) \. ;r _9 l^ .,*^ cl ,J ().i \Y).r-orc YY/A ,.:J+-! i o.rol-:+ ?-f,| s J#*.:l.r-;' I r BMI ,r-cl;" i.,=i.#95* aJ,t, ..r-'[ ;*-r,al-lr .--,_l i-l ;*l a-st_ ,rc5 y.fl : J$)*.:L.; BMI ,lr-; ,i_l;l ! uS.srrt +.Jfl9-i .:1,r-; ;5L- .!)tjjl crll- 1l pl.rS-".-a ,c .;. -1 o.l;-i ,ls .# 6;L\ p ).srLi .p J D r*t--:,_,,aJ;; CF- 4-i 4-?9, I I oJ-: F;l; 9-.f,| t g-,t'|.":*rrl;-^iJ !D i-"t+.9 efu "r.+ tL.i,l 4-Jtt- .r-_l ,.: .;*l or-:-l rl.: *-*.,-L.'-,J o=J;.:l io a5i_! a- 4+f !..r-irlc e*-.51-j-j5 i**t=*i,.jfuL---.Jt,l-! ;tS^l io ,rr- /-L L;t -tUrt t?s.t;15.1 -:y JLf ;lrt-*.gt-o BMI L clr-el ,,r .s_,lr ;* -9l-ir; l- dJit^ 6._LJ.r-3ro ,6; d-^i 9 \t-^.)l. BMI r-_! ,L. 4-.ii-t ,) J,u>9r jr1j' I F_: ;ul-t + +y i+ Ll. l-;:; o.!J giJ:.".xjl Olf+ t-.r",L-, J1 o.r ,l r-> 4J lr.:1r-l jj, r,J t# t *; ,); ,,,: .,-4a 4!*9 -(Jlf,-5 . -,:* Sgt F ,1 ,t .r-U -?,*;.?^ ;i, ,=;; I uji ,-;-liJl j,l>s.C** r.: .l-^i; -9.-.lt- c^iJ 4-Jtl- j,--l ,r.r J ShS+ 6.tl \ ! trf c,cl9---e.ti . .ul,t ..r5;J5 I .A,1.^"-; .,<tt--.> ,.iisr- ori a-*y J-jlf .,- D ..r"-b-l fy!J-:L .,- c,9Lc- .a,L-:- c,iJll- c-1Fl e-L:; ! D ,-'.-L;,-r el- u-Ll f -ft- 4,Jttt_* rt .;*l ocy ,o5 4-Jtt- ,,--! -rJ a;f ,c.-"e +J ;*! .--_l O1 Jr ,t .,5,_ -r,_[ a5..f P-;J 6.F *[-rr .i- .:lilrc D ir*b-l & t BMI 6)L.l .91; .r,L,.grl.r5 .S-.;; , IVF .D ,-,.-L:,_r ,.,Ll1U '.g15 .9Lo ojlgLIntroductionInfertility is defined as inability to become pregnant after one yearunprotected sexual intercourse. Nowadays, 10-15o/o of couples are infertile.Therapeutic procedures for these couples include intrauterineinsemination(IU! and in vitro fertilization(IVF). IVF is usually indicatedfor infertility due to fallopian tube obstruction and abnormalspermatogenesis. There are various surveys about the role of vitamin D inreproductivity and the association of vitamin D serum level withpreeclampsia, insulin resistance and gestational diabetes mellitus. Withregard to importance of fVF success which is affected by different factorsand as there was no similar research in Iran, this study was conducted toevaluate effect of vitamin D serum level, body mass index and calciumserum level on IVF outcome.Material and methods: This study was designed as a cohort one and wasperformed on infertile women due to female problems (without malefactors problem) from March 2016 to March 2017. Patients were selectedbased on inclusion and exclusion criteria. Quality of ovulation wasevaluated according to morphologic characteristics. Number of transferredernbryos (examined by embryologist),age ,number of and quality ofexisting embryos. Time for preservation of embryos and consequence.After IVF procedure pregnancy occurrence was evaluated by BhCGmeasurement 12 and 14 days after embryo transfer and subsequently IVFsuccess was verified by sonography.Result: finding of this study on 40 subjects showed that patients' mean ageis 33.4 years. Vitamin D serum level u'as norlnal in 30%(12 patients).rnildly deficient in 27.5(11 patients), moderately deficient in 32.5%(1,1patients) and it \\'as severely deficient in l0%(4 patients).There was areverse relationship betu'een BMI and number of follicles and embryos inway that u-itli increased BMI the number of follicles and embryos wasdiminished. Hou.er er this reverserelationship was not statisticallysignificant.Ths association between different vitamin D serum level withnumber of lollicles oocltes , embryos and transferred embryos was notstatisticalh' si-enificant.ln our study,association between different vitamin Dserum level u'ith quality of oocyte,chemical and clinical pregnancy wasstatistically significant. As the calcium level was in normal ranges in allsubjects. it was not possible to evaluate its' association with othersvariables.Discussion:Although the reverse relationship between BMI and variablesshowing IVF success didn't reach and statistically significant level. Itshould be considered as a key point and womens' weight should be kept inideal range to reduce adverse effects of weight gain, loss, hormonal changeon ernbryo and ovulation.Higher quality of ovum in addition to higherlevel of vitarniir D could justify chemical and clinical pregnancy success.Current study results about vitarnin D level differ from previous studiesthat rnight be due to low sarnple size. It is recommended to consider aconrprehensive pla,n to corect BMI and vitamin D level.J,"S,frl".-ijfi 9 r.rbto c*il.r41 o;119ObJ.t dta.ro, ,st ilq{ crto.ri 9 ,rS.il;a pgls olS,l,jlc.j+r!,j-it"i -,rS*r;g oaS,.i.jl.r+"U Ot,_L" jl elio or_t+, or.r;+*ti o.,rl. Y I o-r^ J.fit+ ! f g.Gr .9_,91o e.:*o fr-r,* 6L"l 9 ldol-r +JLl $;> L.##a"U OkQ .,*,JJd LL;l"le rf':L-l L 'y.rt-or.J6r':,.!L*;Lr ro lo aU;.-1 +I5-,"i,-,5l; a-.LoL-ii6ln..;*jJiJri -r -L".-.;;t3r.:l;.!.-..l, ir.ir-iL *-;: -- -..:"; i-;l 9,+r la ulj ;q", +i ,-r q L,.s _. '- _ -6tnaa l"fo; .r*fo ,sl#drd .*U Olr_lr,J ,,L-r e'Lu ! d+ oof ,J4tLi 9 r**JS . D cr*t.- 9 db*, aJi,l: e:;:6lqj-c c^2.;JJ,, GI;-il ',LtLr-r .,.ljl; u:r.{ a, orc;.S +rolr- .-,1;k* ,o IVF;L*,"!; J ,lLj 6aa;r .91tsr aa;J *L_;r i^:->\Ytr/atl. 3;'rL ;:";a I.'*r )rl.dal, cLi*looll **- L_rgi_9 ,*5:r'-. l.'.J r5:ii--' ^ -./,;, ilrt )l'v./*,/Lt y't )tu1;,gti;,,x .llAtl ;Up aiytT 1Sy+t-, f.f=t:5O

بررسی رابطه BMI و سطح ویتامین D و کلسیم با نتایج حاصل از IVF در بیماران مراجعه کننده به بخش نازایی بیمارستان افضلی پور

http://eprints.kmu.ac.ir/26899/1/6381.pdf

بررسی رابطه BMI و سطح ویتامین D و کلسیم با نتایج حاصل از IVF در بیماران مراجعه کننده به بخش نازایی بیمارستان افضلی پور

Abstract

Similar works

Full text

Available Versions

Simorgh Research Repository