Ghazi Firozsalari, Farhood

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,,S.,.}.,* o,rS*i,.ll.l.Fi csiJ#J+ .r,i,el ,r-l'.,r.JlS *3- *l: rQl1:;13',c,.t...I t.l La C*lS.f:l* Lrs;4 +l$ cg.rtri .*l+-.1- , eh:. o ,gla;3lr'il J**rr; ,r.lrs.,- cSl, ,-i-l- -r.l g*5 GrE g "l.-.h 6lacS-,Ul--l-rJ#,-r,-G.l3,a;ri t L "'=F.r-=-;al-3r;.lt-, r:S, : L^i^l-r .lLi,,.lLS t ..l lj-*tlirKl, 6, l'' K[i.u-.tS.1 :;3 l--1.-o .ll':' "|\Y10-\Y1P :,J*,^=l Jl-Kerman University of Medical ScinenscsFaculty of MedicineIn Partial Fulfilment of the Requirements for the Degree Master of Science in:Medical PhysiologyTittle:Shilajit effect on the level pro-inflammatory and anti-inflammationcytokines in hepatic injury in male ratsBy: Farhood Ghazi feruozsalariSupervisor: Dr. Nader shahrokhiAdvisors:1- Dr. Mohamd Khaksari HaddadY- Dr. Gholamreza Asadi KaramYear: Y.'lV:o'I5+)) L5-Q/ & t S *" ,"Ju lt 6)l* s nd.)ly\.slari-lp )l ,*--t.i*t b ;I-1J9--L :.!'u9 a.Lal..rlro + e.Vy a(.r,-lr.;i;l rilr .r .srJ ,-Jlo -*i n*" .tlc;l ;l-rJl l .-akJl .[.l9c .s1b .r+t .rL ..*-]&ltr4[ &- y ,-s.Vs" ll i""- dJrt ;,l .]-l -iro l.rJ. r9.i .r sf ;l-r*51 ;i , .,,taptL"; J.lt.i-ru;! .r +t t*-i .,, ,;\Jl s I .t\Jl d* cstbdi;r p +l s-r; p*""d A.B {,) 9) { .rslL; ,9L 4 1L*-9 tl; ; 6.lrz'- Cy y, A' :ta 4i91 9 stgn,_r JU' I .;.Vy :1t-) )9:, .l.Gt" C ;1. ,(B) all-.91r:'. .:[*;l lr.l (A).pryt-l , JiS :,9r5 d .l.Li,r 9 srr-f iLlr: ip u)/a .f *--i-l e,S # I ef L* A. . ,A a:!) )) ,JyS olf ,+. t+..1,5 .rti ljL'r. {,.,,-,"' jl ,., ig- ir B ..-- : -) r ---c'! Y jl .,*" A+;: rr urr- r-5 fll Al*- lr:. rl-r*;l B a;-:J,t ilr + ki- =i,JU- ,lf t e..:t" rrg k-e Yt., m-u kg\a.;Lrr c.>,; ,96tf 4*. )l;.rt i.i-.rj .,, qE'oL;-L;l pl-2.;l ;q; r{ .-f c:- , ;L2: o;9: p["] 1l ,- 'r;.:ri c^il,-r; e.Vy,J*, 4.. jt) &' Jy* \ 4t IL-\ . ,IL-?, IL-\p, TNF- u et- ;1r: s.Vr J.,t, ! .;L;r : tA 4iet-rl.: ";..o1-l l1 :9 a:sL- *.lfl 1si*l-l A y f f. c-l ;y dPi*.l:-l )!.j )9) oy* ) *rL .rqt.sL q--i9 !,\r] ';.atl ,r G.Vs": ,5f $.t5, .r.ux.L ,691r;"- 6lsz, ,6pg,.,2tt-,1. .l-l**r:dA*15 .5ta ojlgAbstractBackground and objective: Cytokines regulate a broad range of biological and pathologicalprocesses. They play an important role in liver damage. Inflammatory and antioxidant factors areimportant causes of liver damage Because, Shilajit known as an anti-inflammatory and antioxidantagent. Therefore, major aim of this study was determine the effect of Shilajit on levels ofproinflammatory and anti-inflammatory cltokines in liver injury.Materials and Methods: A. male rats Wistar were randomly divided into two groups: A,BCategory respectively, Each one has o groups: control, acetaminophen (A) or BDL( B), low dose,high dose and vehicle , All groups except the control group, in category A, received o' ' mg/ kgacetaminophen via ip injection, and in category B was performed bile duct obstruction .Then incategory A, Y hours and in category B seven days after injury, for one and six days in treatmentgroups with drug and vehicle group received l o . mg / kg (low dose) and Y o' mg / kg (high dose)shilajit and or distilled water as vehicle,respectively. After completing treatment, liver sampleswere taken for laboratory analysis.Results: Treatment with low - dose of Shilajit reduced IL-\ ', IL-1, IL-'lB, and TNF- u levels,which increased by the use a single dose of o . . mg/kg of acetaminophen.Conclusion: Shilajit iseffective in reduce inflammation and liver damage caused by of consumption high-dose ofacetaminophenKeywordz Shilajit , acetaminophen, bile duct, cytokine, liver

Shilajit effect on the level pro- inflammatory and anti - inflammation cytokines in hepatic injury in male rats

http://eprints.kmu.ac.ir/26792/2/6311.pdf

Shilajit effect on the level pro- inflammatory and anti - inflammation cytokines in hepatic injury in male rats

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