Gambaran Histopatologik Lambung Tikus Wistar (Rattus Norvegicus) Yang Diinduksi Asam Mefenamat Dan Diberi Susu Kental Manis

Abstract

: Empirically, sweet condensed milk is often consumed by gastritis patients with acute gastritis to relieve the symptoms of epigastric pain. Its amphoteric acidity (pH 6,5 - 6,7), sweet taste, nutritional and oligosaccharides contents are some factors that are predicted to influence the relieve of epigastric pain. Acute gastritis can be induced by NSAIDs, such as mefenamic acid. This study aimed to reveal the histopathological features of the gaster of Wistar rats (Rattus norvegicus) induced with mefenamic acid and fed with sweet condensed milk. This was laboratory experimental study using 21 Wistar rats. Rats were divided into three groups (seven rats in each group). Group A was the negative control, group B was induced with mefenamic acid 23,25 mg/day for seven days, and group C were induced with mefenamic acid 23,25 mg/day and administered with sweet condensed milk 0,8 ml/day simultaneously for seven days. All rats were terminated on day 8. The results showed that histopathological features of the gaster of Wistar rats had less inflammatory cells and more regenerated cells than that of rats in group B. Conclusion: Histopathological features of gaster of Wistar rats induced with mefenamic acid and treated with sweet condensed milk showed milder signs of acute gastritis and better cell regeneration than that of Wistar rat not treated with sweet condensed milk