Natural ventilation for dwellings in tropical wet regions is very important for health. The requirement for natural ventilation is measured in air change rate (ACH) constituting of the availability of fresh air, quality of air circulation, heat losses, and unwanted gasses in the room. Wind speed is useful for accelerating evaporative cooling process and thus plays an important role for thermal comfort in the interior room. Local wind conditions affects the ventilation of a building and therefore might cause problems in predicting the natural ventilation and thermal comfort in a high-rise building, especially in the area and orientation of an opening that is not perpendicular to the wind direction. Ventilation parameters that are to be observed are the air flow rate and air change (ACH) that are gained from a simulation using the AILOS software. The results show that if the opening orientation is at the wind shadow zone, the interior space will not receive wind, it obtains sucking pressure instead. The design of an opening should focus on the area of inlet and outlet because when ACH does not increase, consequently internal wind speed becomes low and thermal comfort will not be met