Uji Diagnostik Pemeriksaan Osteosklerotik Tulang dengan Sistem Radiografi Digital

Abstract

Diagnostic test of bone osteosclerotics examination using digital radiography systemBackground: The interpretation of a conventional röntgen images have a high degree of subjectivity due to the limitation of humansight. The computationally detection help establish the accuracy of diagnosis of the radiologist. According to our knowledge, there has not been previous research on this issue in Indonesia. The research was aimed to examine a Matlab based software to determine the diagnostic value in the diagnosis of osteosclerotic bone.Methods: This study was a diagnostic test which was conducted in Radiology Department of Dr. Kariadi Hospital Semarang, Dr.Sardjito Hospital Yogyakarta and Bethesda Hospital Yogyakarta, April to August 2009. The radiographs of bone osteosclerotic resulted from computed radiography (CR) test results were taken consecutively, interpreted by a radiologist which was supported by the Anatomical Pathology Laboratory examination as a gold standard. Afterwards these steps were done respectively: classify patients as a normal or osteosclerotic patients based on the cut off point that was determined, calculate the value of the diagnostic by analysis of 2x2 tables, determine the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), anddetermine the optimal of COP (cut off point) using ROC procedure.Results: From the results of diagnostic tests of bone radiographs these following parameter values was obtained: AUC value of 97.6% (95% CI: 94.4%-100%), the optimal cut off point for bone oseosclerotic COP ≥1.05 with a sensitivity value of 93.0% and a specificity of 89.1%. Suitability kappa value of 0.818 K (95% CI: 0.757 to 0.879).Conclusion: The radiographic examination of the results of CR using Matlab-based software can be used to diagnose boneosteosclerotic with high sensitivity and specificity