'Faculty of Agriculture, Sebelas Maret University'
Abstract
Ade R, Rai MK. 2010. Colchicine, current advances and future prospects. Nusantara Bioscience 2: 90-96. Colchicine isa toxic natural compound and secondary metabolite commonly produced by plants like Colchicum autumnale and Gloriosa superba. Itis originally used to treat rheumatic complaints, especially gout, and still finds its uses for these purposes today despite dosing issuesconcerning its toxicity. It is also prescribed for its cathartic and emetic effects. Initially oral colchicine has not been approved as a drugby U.S. Food and Drug Administration (FDA). But now FDA approved colchicine as a drug for some disorders. Colchicine's presentmedicinal use is in the treatment of gout and familial mediterranean fever. It is also being investigated for its use as an anticancer drug.In neurons, axoplasmic transport is disrupted by colchicine. Due to all the pharmacological application of colchicine, there is urgentneed to enhance the properties and increase the production of colchicine with the help of in vitro technologies. The present review ismainly focused on the chemistry of colchicine, its medicinal uses and toxicity
