A descriptive study to assess the knowledge of poly cystic ovarian disease among girls in a selected college at Kancheepuram District, Tamilnadu. 140 samples were selected by using convenience sampling technique. Self-administered questionnaires were used to assess the knowledge of poly cystic ovarian disease. The result showed that 0.71% of the girls had excellent knowledge 2.14% of the girls had very good knowledge,0% of the girls had good knowledge, 13.57% of the girls had average knowledge, 83.7% of the girls had below average knowledge