Antibacterial activity of aqueous and organic root bark extracts of Gliricidia sepium were investigated against S. aureus, B. subtilis, C.pyogenes, S. typhi and E. coli using the disc diffusion method. The water and ethanolic extracts showed inhibitory effects on the microorganisms under study. The n-hexane extract was not active on all the microorganisms. The results showed that the plant extracts of Gliricidia sepium would be useful as antifungi, antibacterial and anti-inflammator