Nat Commun

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 7 10(-15)) and HLA-B (rs2922994, P=2.43 7 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.P01 CA087969/CA/NCI NIH HHS/United StatesHHSN268201100004I/HL/NHLBI NIH HHS/United StatesCA098122/CA/NCI NIH HHS/United StatesUM1 CA167552/CA/NCI NIH HHS/United StatesN01RC37004/RC/CCR NIH HHS/United StatesUL1 TR000430/TR/NCATS NIH HHS/United StatesCA167552/CA/NCI NIH HHS/United StatesN01 PC067009/CN/NCI NIH HHS/United StatesN02-PC-71105/PC/NCI NIH HHS/United StatesHHSN268201100001I/HL/NHLBI NIH HHS/United StatesN01-RC-45035/RC/CCR NIH HHS/United StatesP30 CA016672/CA/NCI NIH HHS/United StatesP30 CA016087/CA/NCI NIH HHS/United StatesHHSN261201000140C/CA/NCI NIH HHS/United StatesCA97274/CA/NCI NIH HHS/United StatesN01 PC067010/PC/NCI NIH HHS/United StatesR01 CA098122/CA/NCI NIH HHS/United StatesU01 HG007033/HG/NHGRI NIH HHS/United StatesK07 CA115687/CA/NCI NIH HHS/United StatesCA098566/CA/NCI NIH HHS/United StatesR21 CA178800/CA/NCI NIH HHS/United StatesHHSN268201100046C/HL/NHLBI NIH HHS/United StatesCAPMC/ CIHR/CanadaCA87969/CA/NCI NIH HHS/United StatesUM1 CA182934/CA/NCI NIH HHS/United StatesN01 PC067008/PC/NCI NIH HHS/United StatesHHSN268201100003C/WH/WHI NIH HHS/United StatesCA49449/CA/NCI NIH HHS/United StatesR01CA154643/CA/NCI NIH HHS/United StatesP30 ES000260/ES/NIEHS NIH HHS/United StatesP30 CA008748/CA/NCI NIH HHS/United StatesR01 CA129539/CA/NCI NIH HHS/United StatesR25 CA098566/CA/NCI NIH HHS/United StatesU58 DP000807/DP/NCCDPHP CDC HHS/United StatesN01-PC-67009/PC/NCI NIH HHS/United StatesCA149445/CA/NCI NIH HHS/United StatesR01 CA154643/CA/NCI NIH HHS/United StatesR01 CA062006/CA/NCI NIH HHS/United StatesN01 PC065064/PC/NCI NIH HHS/United StatesUL1 TR000135/TR/NCATS NIH HHS/United StatesHHSN271201100004C/AG/NIA NIH HHS/United StatesR01 CA098661/CA/NCI NIH HHS/United StatesR01CA1046282/CA/NCI NIH HHS/United StatesHHSN268201100002C/WH/WHI NIH HHS/United StatesP30 CA015083/CA/NCI NIH HHS/United StatesR01 CA092153/CA/NCI NIH HHS/United StatesHHSN261201000035I/CA/NCI NIH HHS/United StatesUL1 TR000142/TR/NCATS NIH HHS/United StatesImNIH/Intramural NIH HHS/United States5R01 CA69669-02/CA/NCI NIH HHS/United StatesHHSN261201000035C/PC/NCI NIH HHS/United StatesHHSN261201000034C/CA/NCI NIH HHS/United StatesP30 CA033572/CA/NCI NIH HHS/United StatesP50 CA097274/CA/NCI NIH HHS/United StatesR01 CA049449/CA/NCI NIH HHS/United StatesHHSN268201100002I/HL/NHLBI NIH HHS/United StatesP30 CA016359/CA/NCI NIH HHS/United StatesN01CO12400/CA/NCI NIH HHS/United StatesN01 CN045165/CN/NCI NIH HHS/United StatesU01 CA049449/CA/NCI NIH HHS/United StatesR01 CA149445/CA/NCI NIH HHS/United States#1U58 DP000807-01/DP/NCCDPHP CDC HHS/United StatesP50 CA97274/CA/NCI NIH HHS/United StatesHHSN268201100001C/WH/WHI NIH HHS/United StatesHHSN268201100004C/WH/WHI NIH HHS/United StatesES000260/ES/NIEHS NIH HHS/United States2015-02-09T00:00:00Z25569183PMC4287989866