Nat Methods

Abstract

Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D) multielectrode implants. This approach allowed us to isolate up to 1,800 neurons (units) per animal and simultaneously record the extracellular activity of close to 500 cortical neurons, distributed across multiple cortical areas, in freely behaving rhesus monkeys. The method is expandable, in principle, to thousands of simultaneously recorded channels. It also allows increased recording longevity (5 consecutive years) and recording of a broad range of behaviors, such as social interactions, and BMI paradigms in freely moving primates. We propose that wireless large-scale recordings could have a profound impact on basic primate neurophysiology research while providing a framework for the development and testing of clinically relevant neuroprostheses.20142014-12-01T00:00:00ZT32 GM008441/GM/NIGMS NIH HHS/United StatesDP1MH099903/DP/NCCDPHP CDC HHS/United StatesR01NS073952/NS/NINDS NIH HHS/United StatesDP1 MH099903/MH/NIMH NIH HHS/United StatesUL1 TR001117/TR/NCATS NIH HHS/United StatesR01 NS073952/NS/NINDS NIH HHS/United StatesDP1 OD006798/OD/NIH HHS/United States24776634PMC416103