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research
Glutathione-s-transferase modified electrodes for detecting anticancer drugs
Authors
Antonio A. Pupim Ferreira
Po-Jung Jimmy Huang
+4 more
Juewen Liu
Elsa M. Materon
Maria Del Pilar Taboada Sotomayor
Ademar Wong
Publication date
7 March 2014
Publisher
'Elsevier BV'
Doi
Cite
Abstract
The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.bios.2014.02.070. © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/With the fast growth of cancer research, new analytical methods are needed to measure anticancer drugs. This is usually accomplished by using sophisticated analytical instruments. Biosensors are attractive candidates for measuring anticancer drugs, but currently few biosensors can achieve this goal. In particular, it is challenging to have a general method to monitor various types of anticancer drugs with different structures. In this work, a biosensor was developed to detect anticancer drugs by modifying carbon paste electrodes with glutathione-s-transferase (GST) enzymes. GST is widely studied in the metabolism of xenobiotics and is a major contributing factor in resistance to anticancer drugs. The measurement of anticancer drugs is based on competition between 1-chloro-2,4-dinitrobenzene (CDNB) and the drugs for the GST enzyme in the electrochemical potential at 0.1 V vs. Ag/AgCl by square wave voltammetry (SWV) or using a colorimetric method. The sensor shows a detection limit of 8.8 μM cisplatin and exhibits relatively long life time in daily measurements.University of Waterloo || Natural Sciences and Engineering Research Council || Emerging Leaders in the Americas Program |
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Acervo Digital da Unesp
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info:doi/10.1016%2Fj.bios.2014...
Last time updated on 23/03/2019