Bailey, Timothy L.

Cloonan, Nicole

Gardiner, Brooke B.

Grimmond, Sean M.

Keys, Janelle R.

Nourbakhsh, Ehsan

Perkins, Andrew C.

Tallack, Michael R.

Wainwright, Elanor N.

Whitington, Tom

Yuen, Wai Shan

English

University of Queensland eSpace

Erratum
Genome Research 20: 1052–1063 (2010)
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells
Michael R. Tallack, Tom Whitington, Wai Shan Yuen, Elanor N. Wainwright, Janelle R. Keys,
Brooke B. Gardiner, Ehsan Nourbakhsh, Nicole Cloonan, Sean M. Grimmond, Timothy L. Bailey,
and Andrew C. Perkins
The authors recently have been made aware by colleagues Jim Hughes and Doug Higgs of an error in Figure 2,
which reports occupancy of KLF1 at the mouse alpha-globin locus (Fig. 2A). The authors’ strategy for
mapping KLF1 ChIP-seq sequencing tags to the mm9 genome only when they are found to be unique has
aberrantly eliminated the potential to observe occupancy at the Hba-a1 and Hba-a2 genes, which are
identical and have arisen from gene duplication. Below is an alternate version of Figure 2 in which mapping
has been corrected to allow occupancy to be observed at these genes. It becomes obvious that KLF1 occupies
not only the DNase I hypersensitive sites, but also the promoters of Hba-a1 and Hba-a2. The authors thank
Jim Hughes in particular for providing them with the data to correct this figure. The legend for this figure
remains unchanged.
Figure 2. KLF1 binds the mouse alpha- and beta-globin loci at proximal promoters and locus control regions. (A) An image of the murine alpha-
globin gene cluster and the upstream locus control region regulatory element (HS-31 to HS-8) from the UCSC Genome Browser. Genes and DNase
I hypersensitivity (HS) sites are represented in the top track. KLF1 ChIP-seq signal (maroon) and Input ChIP-seq signal (blue) tracks are also shown
together with KLF1 peak calls (KLF1 Peaks). An additional track describing GATA1 ChIP-seq peak calls from Cheng et al. (2009) is shown (GATA1 Peaks)
together with a mammalian conservation track (Mammal Cons). (B) An image of the murine beta-globin gene cluster and locus control region flanked
by olfactory receptor genes from the UCSC Genome Browser. Genes and DNase I HS sites are represented in the top track. Other tracks are presented as
for A.
1748 Genome Research
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20:1748 2010 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/10; www.genome.org
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Erratum
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Michael R. Tallack, Tom Whitington, Wai Shan Yuen, et al.
erythroid cells
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary
  
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A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells (vol 20, pg 1052, 2010)

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A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells (vol 20, pg 1052, 2010)

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