Bek, Toke

Davidsen, Rasmus Schmidt

Hansen, Ole

Keller, Stephan Sylvest

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Jan 01, 2018Photovoltaic subretinal implants for blind patientsDavidsen, Rasmus Schmidt; Bek, Toke; Keller, Stephan Sylvest; Hansen, OlePublished in:Book of Abstracts, Sustain 2017Publication date:2017Document VersionPublisher's PDF, also known as Version of recordLink back to DTU OrbitCitation (APA):Davidsen, R. S., Bek, T., Keller, S. S., & Hansen, O. (2017). Photovoltaic subretinal implants for blind patients.In Book of Abstracts, Sustain 2017 [H-9] Technical University of Denmark (DTU).     Photovoltaic subretinal implants for blind patients  Rasmus Schmidt Davidsen1*, Toke Bek2, Stephan Sylvest Keller1, Ole Hansen1 1: Department of Micro- and Nanotechnology, Technical University of Denmark (DTU) 2: Department of Ophthalmology, Aarhus University Hospital , *Corresponding: rasda@nanotech.dtu.dk  Background Retinal diseases are the most frequent causes of visual loss in the Western world. Two of the prominent diseases are age-related macular degeneration (AMD) and retinitis pigmentosa (RP). The pathophysiology of AMD and RP is unknown, but a central event leading to visual loss in these diseases is the degeneration of retinal photoreceptors. At present, there are no effective treatments of photoreceptor degeneration. A promising potential solution for partial restoration of sight is to implant a solar cell that translates incoming light into an electrical signal to be transmitted to the secondary neurons in the retina [1-4]. We propose a 1-diode subretinal prosthesis design utilizing 3D electrodes made from pyrolytic carbon (Figure 1). The final device would rely on via holes between isolated electrodes (pixels) enabling sufficient nutrient flow to the cells and charge transport from each local electrode to a common return electrode on the rear of the device. A sketch of the device is shown in Figure 1 (right).   Figure 1:  SEM-images of carbon electrodes at 72x(left) and 1700x(middle) and sketch of the device (right). Fabrication of complete devices is currently ongoing and future work includes measuring potentials from porcine retinal tissue when the photovoltaic implant is placed in contact with tissue and illuminated with an appropriate light source in order to realize photovoltaic stimulation of neurons.  Acknowledgements The authors gratefully acknowledge the funding support from Velux Fonden (project nr. 13891) and Young Investigator Program of the Villum Foundation, project no. VKR023438.   References [1] Y. Mandel, G. Goetz, D. Lavinsky, P. Huie, K. Mathieson, L. Wang, T. Kamins, L. Galambos, R. Manivanh, J. Harris, D. Palanker ”Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials” Nature communications 4 (2013) 1980. doi:10.1038/ncomms2980  [2] S. Y. Kim, S. Sadda, J. Pearlman, M. S. Humayun, E. de Juan Jr, B. M. Melia, W. R. Green “Morphometric analysis of the macula in eyes with disciform age-related macular degeneration” Retina 22 (2002) 471–477. doi: 10.1097/00006982-200208000-00012 [3] F. Mazzoni, E. Novelli, E. Strettoi “Retinal ganglioncells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration” J. Neurosci. 28 (2008) 14282–14292. doi:10.1523/JNEUROSCI.4968-08.2008 [4] J. L. Stone, W. E. Barlow, M. S. Humayun, E. de Juan Jr, A. H. Milam “Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa” Arch. Ophthalmol. 110 (1992) 1634–1639.doi:10.1001/archopht.1992.01080230134038 1.95 mm 35.97 µm 14.93 µm Sustain Abstract H-9

Photovoltaic subretinal implants for blind patients

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Photovoltaic subretinal implants for blind patients

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