Two oligoresveratrol, namely balanokarpol (1) and ampelopsin H (2) had been isolated from the steam bark of Hopea odorata (Dipterocarpaceae). The structure of this compound were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR 1D and 2D). The activity of these compounds was evaluated against the 2-deoxyribose degradation induced by the hydroxyl radical generated via a Fenton-type reaction. The result of this study showed that activity each compounds as radical hydroxyl scavenger of balanocarpol, and ampelopsin H with an IC50 1802,3 and 4840,0 g/ml. respectively. Each compound showed low activity. Vitamin C (IC50 83,9 g/ml) and butylated hydroxyl toluene (1328,0 g/ml) used as positif control. These results suggest that oligoresveratrols from stem bark of H. odorata may be useful as potential sources of natural antioxidants.
Keyword: balanocarpol; ampelopsin H; antioxidant; dipterocarpaceae
FMIPA, 2006 (PEND. KIMIA
