Effects of husbandry and low-dose lipopolysaccharide challenge on the acute phase response of young pigs

Abstract

End of project reportIn recent years, concern has grown for the welfare of domesticated animals in different production systems (Appleby and Hughes, 1997). Poor welfare can result in poor performance and productivity. However, the consumers are also requesting more welfare-friendly systems, as reflected by the importance that ‘organic’ and ‘free-range’ products have gained in our markets. Furthermore, there are ethical reasons for safeguarding the welfare of animals in our care. Thus, it is scientists’ task to be able to develop methods and techniques that can help to assess the welfare objectively. Traditionally, welfare assessment relied on the study of behaviour and the measurement of endocrine parameters. Acute phase response mediators and products, such as pro-inflammatory cytokines and acute phase proteins, emerged recently as potential indicators of infection and herd health status (Eckersall, 2000; Petersen et al., 2004). Thus, investigating the effects of husbandry and low-dose lipopolysaccharide (LPS) challenge on the acute phase response of young pigs can give valuable information on the use of these immune parameters as health and welfare indicators in pigs.Teagasc acknowledges the support of National Development Programme Funds (NDP) in the financing of this research projec