Helicobacter pylori infection is one of the most common human infections which have
been associated with many upper gasterointestinal complications. Different treatment
regimens for Helicobacter pylori eradication have been used. One of these regimes is the
quadruple therapy regimen which metronidazole is one of the medications. In recent years
several reports on H. pylori resistance to this antibiotic has been presented. This study was
performed to compare the effects of garlic and peppermint extract combination with
metronidazole in the treatment of Helicobacter pylori infection. In this randomized double
blind clinical trial, 142 patients who were eligible for inclusion in study after completing the
questionnaire and consent form were randomly divided into two groups, receiving garlic and
peppermint extract or metronidazole. Moreover, for both groups the drugs; amoxicillin,
omeprazole and bismuth were also administrated. Two weeks after drug administration
completion, urease breath test (UBT) was performed and based on the obtained data, the
recovery rate in the two groups were compare using SPSS 16 software T-test and Ki squire.
The patients mean age was 43.89± 13.37 years. Evaluating the age and sex factors, we found
no significant difference between two groups. Results suggest that although the combination
of amoxicillin, omeprazole, bismuth plus garlic and peppermint was not successful in the
eradication of Helicobacter pylori such as the quadruple therapy, but less than half of cases
lead to eradication of Helicobacter pylori infection
