EFFICACY OF PROPHYLACTIC TRANEXAMIC ACID FOR PREVENTION OF HEMORRHAGE IN HEMOPHILIC PATIENTS

Abstract

Hemophilia A and B are two type of coagulation disorders with specific complication due to disease and its treatment consequences. The prevention of truma and factor replacement are cornerstone of therapy in hemophilia. In this study, the efficacy of prophylactic tranexamic acid (TEA) in reducing bleeding episodes and factor replacement was evaluated. In this study, 28 hemophilic patients were divided into two groups, group 1: TEA was used for 2 months (20mg/kg, oral tablet). In groupe2 any adjunctive therapy not used. In-group 1 bleeding episode and need for factor replacement, were decreased significantly (p<0.05). But surprisingly PIT was increased significantly in-group 1, probably due to decreased factor replacement by the pts. In groups, 2 bleeding episode and need for factor replacement were not+ different prior and during study. Our experience would suggest that daily prophylactic use of TEA is effective in reducing bleeding episodes in hemophilia, but due to increased PTT (probably due to decreased factor replacement by the pts) the risk for life threatening bleeding would be high, and also complete block of fibrinolytic pathway during TEA therapy is a dangerous consequence. So we do not recommend the use of TEA as prophylaxis in hemophiliac patients