Introduction: Endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (MHC) proteins. On the
other side, Purine-rich element-binding protein β (pur) decreases the αMHC gene expression. The aim of this study was to determine the
impact of exercise endurance training on pur gene expression in the heart of Wistar rats.
Methods: Fourteen rats have been kept under controlled conditions and after familiarizing with training protocol, they were divided into
control groups and experimental groups. The experimental group performed a 10-week treadmill running program for 30 min/day, 5
days/week. 48 hours after the last training session, the rats were anesthetized and the heart and their left ventricle were taken out and pur
expression was measured using real time PCR method. All data were analyzed using t test.
Results: In this study, the results of M-mode echocardiography showed that endurance training led to cardiac hypertrophy. After endurance
training, the heart weight, especially the left ventricular weight significantly increased. The pur gene expression significantly decreased in the
left ventricular tissue of endurance-trained rats.
Conclusion: The results of this study revealed that endurance training has considerable effects on heart size and pur gene expression. The
pur gene also repressed MHC gene expression; it seems that the changes in heart structure related to MHC gene expression
