Background and Aim: Helicobacter pylori infection is currently endemic
worldwide health problem. The infection causes variety of gastrointestinal (GI)
symptoms such as chronic gastritis, peptic ulcer, and gastric adenocarcinoma. It is
clear that smoking is important to the development of disorders like intestinal disease.
This study determines the relationship between H.pylori density and smoking.
Materials and Methods: The study was performed in 247 patients (20-80 years)
both sexes, with dyspepsia symptoms referred to Hajar hospital. Demographic data
were recorded, such as age and smoking history. Patients were checked by 16 SrRNA
and glmM genes polymerase chain reaction for H. pylori. Density of H.pylori graded
according to the number of H.pylori bacteria counted in light microscopy by (x1000
magnified).also patient had to have smoked for more than 1 year.
Results: We observed 67.61% of patients (167 of 247) were positive for H. pylori, and
32.39% were negative (80 of 247). In patients with dyspepsia, 36.4% in 20-40 age
range, 42.1% in 41-61 and 21.5% in 62-80. Of total patients, 57.1% were smokers and
in this number, 78.01% were H. pylori positive. Also study showed, in smokers and
3th age range, sever density of H.pylori was more than nonsmokers and other ranges.
A significant difference (P<0.05) was observed when we compared density of bacteria
by age and smoker with nonsmoker groups.
Conclusions: H.pylori sever density can be related by cigarette smoking and age