Background and aims: Many factors could affect on the health status. This study aimed to assess the general health status of high-school students in Ilam province in 2014. Methods:This cross– sectional study determined the general health status of high-school students in Ilam, located in west of Iran in 2014. The samples were selected by multi-stage random sampling method. Data were collected by a two-part questionnaire. The first part of the questionnaire included the personal characteristics and the second part of the questionnaire contained General Health Questionnaire- 28 (GHQ-28. Results: A total of 381 students were enrolled in this study. Overall 236 (61.9) of students had healthy status. In addition, 145 (38.1) of all participants had disorder in one or more dimensions of their general health status. The mean±SD of overall score of general health was 5.78±4.53 in healthy status students and 7.83±5.72 in disorder status students. The difference in overall score of general health was statistically significant between healthy and disorder status students (P<0.001). Moreover, the differences in the age, school grade, parental education and number of children living with families were significant between healthy and disorder status students (P<0.05). Conclusion: General health is an important issue among adolescents and high-school students who are at high risk of general health disorder. Therefore, the regular evaluation of their general health status is necessary for planning an appropriate counseling program
