Background: Leishmaniasis is a widespread problem, especially in the tropical and subtropical countries. Since understanding epidemiologic and geographical distribution of the diseases is necessary for prevention and control of Leishmaniasis. This study was conducted for epidemiological survey of cutaneous Leishmaniasis in North Khorasan Province, using GIS during the years 2006-2013. Methods: In this cross-sectional study, data of the Leishmaniasis patients between the years 2006 and 2013 collected from the different districts ofN. Khorasan Province. The gathered data was analyzed by using Spps16 statistical software and chi-square test. Results:Data concerning 2831 patients with CL were collected.The maximum outbreak of the disease occurred in 2011 and theminimum occurrence was reported to be in2008. The mean age of the study population was22/80 ± 18/08 and the maximum cases of infection were observed in age group of 16-30 years. 58/6 percent of the patients were male and 53/5 percent of them lived in the villages. The maximum infection of the disease was observed in Esfarayen with 1095 people (38/7 percent). There was a significant relationship between the gender and age of the patients and cutaneous Leishmaniasis (
